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KMID : 0545119920020020092
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Journal of Microbiology and Biotechnology
1992 Volume.2 No. 2 p.92 ~ p.97
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Microbial Transformation of Bioactive Diterpenoids from Acanthopanax koreanum by Fusarium oxysporum
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KIM, YOUNG HO
HYUN, SEOUNG HAE/KIM HANG SUB/LEE, SUNG WOO/KIM, DONG HYUN/LEE, JUNG JOON
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Abstract
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Microbial transformation of (-)kaur-16-en-19-oic acid and (-)pimara-9(11),15-dien-19-oic add from A. koreanum was investigated. Throughout the screening of the capability of metabolizing these bioactive diterpenoids, two microorganisms have chosen among various fungi and streptomycetes tested. Scale-up fermentation with Fusarium oxysporum KCTC 6051 produced two metabolites related to the precursor diterpenoids. The two metabolites were isolated by column chromatography and identified by chemical and spectroscopic methods as 2β,16α-dihydroxy kauran-19-oic acid and 16α-hydroxy kauran-19-oic acid. However any microorganisms capable to transform (-) pimara-9(11),15-dien-19-oic acid was not screened in this condition.
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